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USMLE Step 3 is open to candidates who already hold their USMLE Step 1 and Step 2 certificates. Step 3 is a two-day exam that assesses whether candidates are able apply medical knowledge and understanding of biomedical and clinical science essential to unsupervised medical practice. This is the final USMLE exam which leads to the license to practice medicine without supervision - the ultimate goal of medical students and professionals willing to practice medicine in the United States. Step 3 represents the final assessment of physicians assuming independent responsibility for delivering general medical care.

USMLE stands for United States Medical Licensing Examination. This is a series of medical exams coming in a few stages that all new doctors need to pass (starting from their time in med school) to be able to practice medicine.
Step 1 of the USMLE (United States Medical Licensing Examination) is the first part of the United States Medical Licensing Examination. It is open to medical school student and graduates to assess their ability to apply important concepts fundamental to the practice of medicine. While American medical students usually take USMLE Step 1 at the end of the second year of medical school, all graduates of foreign medical schools must take this exam is they intend to practice medicine in the United States.
USMLE Step 2 is open to all medical students and graduates who have successfully passed the USMLE Step 1. The Step 2 exam assesses the candidates' medical knowledge, skills, and understanding of clinical science essential for patient treatment and care, health promotion and disease prevention.
Reference: http://www.usmle.org/step-1/#question-formats
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| Section | Objectives |
|---|---|
| Topic 1: Gastrointestinal System | - Digestive System Disorders
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| Topic 2: Reproductive System | - Male and Female Reproductive Health
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| Topic 3: Cardiovascular System | - Cardiac and Vascular Disorders
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| Topic 4: Renal and Urinary System | - Kidney and Urinary Disorders
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| Topic 5: Respiratory System | - Pulmonary Medicine
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| Topic 6: Musculoskeletal System | - Bones, Joints, and Muscles
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| Topic 7: Central and Peripheral Nervous Systems | - Neurologic Disorders
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| Topic 8: Multisystem Processes and Disorders | - Systemic Conditions
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| Topic 9: Endocrine System | - Hormonal Regulation and Disease
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| Topic 10: General Principles | - Foundational Medical Sciences
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| Topic 11: Skin and Related Connective Tissue | - Dermatologic Conditions
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| Topic 12: Hematopoietic and Lymphoreticular Systems | - Blood and Immune Disorders
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| Topic 13: Human Development | - Growth and Development
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